U \u00e1c t\u00ednh, m\u1ed9t lo\u1ea1i ung th\u01b0 da \u00e1c t\u00ednh, v\u1eabn l\u00e0 m\u1ed9t trong nh\u1eefng b\u1ec7nh nguy hi\u1ec3m nh\u1ea5t do kh\u1ea3 n\u0103ng lan r\u1ed9ng nhanh ch\u00f3ng v\u00e0 kh\u1ea3 n\u0103ng kh\u00e1ng l\u1ea1i c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb truy\u1ec1n th\u1ed1ng nh\u01b0 h\u00f3a tr\u1ecb. M\u1eb7c d\u00f9 ch\u1ec9 chi\u1ebfm 5% c\u00e1c tr\u01b0\u1eddng h\u1ee3p ung th\u01b0 da, n\u00f3 l\u1ea1i l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y ra ph\u1ea7n l\u1edbn c\u00e1c ca t\u1eed vong li\u00ean quan \u0111\u1ebfn c\u00e1c kh\u1ed1i u n\u00e0y. T\u1ef7 l\u1ec7 m\u1eafc b\u1ec7nh \u0111\u00e3 t\u0103ng m\u1ea1nh trong nh\u1eefng th\u1eadp k\u1ef7 g\u1ea7n \u0111\u00e2y, \u0111\u1eb7c bi\u1ec7t l\u00e0 \u1edf nh\u1eefng ng\u01b0\u1eddi tr\u00ean 60 tu\u1ed5i t\u1ea1i ch\u00e2u \u00c2u, B\u1eafc M\u1ef9 v\u00e0 ch\u00e2u \u0110\u1ea1i D\u01b0\u01a1ng.<\/p>\n
Li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch \u0111\u00e3 \u0111\u00e1nh d\u1ea5u m\u1ed9t b\u01b0\u1edbc ngo\u1eb7t trong vi\u1ec7c \u0111i\u1ec1u tr\u1ecb u \u00e1c t\u00ednh, b\u1eb1ng c\u00e1ch t\u1eadn d\u1ee5ng \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch \u0111\u1ec3 ch\u1ed1ng l\u1ea1i b\u1ec7nh t\u1eadt. C\u00e1c t\u1ebf b\u00e0o ung th\u01b0 u \u00e1c t\u00ednh th\u01b0\u1eddng mang nhi\u1ec1u \u0111\u1ed9t bi\u1ebfn do t\u1ed5n th\u01b0\u01a1ng g\u00e2y ra b\u1edfi tia c\u1ef1c t\u00edm. Nh\u1eefng \u0111\u1ed9t bi\u1ebfn n\u00e0y t\u1ea1o ra c\u00e1c protein b\u1ea5t th\u01b0\u1eddng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c h\u1ec7 th\u1ed1ng mi\u1ec5n d\u1ecbch nh\u1eadn di\u1ec7n, khi\u1ebfn lo\u1ea1i ung th\u01b0 n\u00e0y \u0111\u1eb7c bi\u1ec7t nh\u1ea1y c\u1ea3m v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb k\u00edch th\u00edch h\u1ec7 mi\u1ec5n d\u1ecbch t\u1ef1 nhi\u00ean c\u1ee7a c\u01a1 th\u1ec3.<\/p>\n
C\u00e1c li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch ho\u1ea1t \u0111\u1ed9ng b\u1eb1ng c\u00e1ch ch\u1eb7n c\u00e1c c\u01a1 ch\u1ebf m\u00e0 c\u00e1c t\u1ebf b\u00e0o kh\u1ed1i u s\u1eed d\u1ee5ng \u0111\u1ec3 tr\u1ed1n tr\u00e1nh s\u1ef1 gi\u00e1m s\u00e1t c\u1ee7a h\u1ec7 mi\u1ec5n d\u1ecbch. V\u00ed d\u1ee5, c\u00e1c lo\u1ea1i thu\u1ed1c nh\u1eafm v\u00e0o c\u00e1c protein PD-1, CTLA-4 ho\u1eb7c LAG-3 gi\u00fap k\u00edch ho\u1ea1t l\u1ea1i c\u00e1c t\u1ebf b\u00e0o lympho T, nh\u1eefng t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch c\u00f3 kh\u1ea3 n\u0103ng ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0. Nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y, \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 ch\u1ea5t \u1ee9c ch\u1ebf \u0111i\u1ec3m ki\u1ec3m so\u00e1t mi\u1ec5n d\u1ecbch, \u0111\u00e3 c\u1ea3i thi\u1ec7n \u0111\u00e1ng k\u1ec3 tu\u1ed5i th\u1ecd c\u1ee7a b\u1ec7nh nh\u00e2n m\u1eafc u \u00e1c t\u00ednh giai \u0111o\u1ea1n ti\u1ebfn tri\u1ec3n. C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1c li\u1ec7u ph\u00e1p n\u00e0y c\u00f3 tu\u1ed5i th\u1ecd v\u01b0\u1ee3t qu\u00e1 nhi\u1ec1u n\u0103m, trong khi tr\u01b0\u1edbc \u0111\u00e2y ch\u1ec9 k\u00e9o d\u00e0i v\u00e0i th\u00e1ng.<\/p>\n
Tuy nhi\u00ean, kh\u00f4ng ph\u1ea3i t\u1ea5t c\u1ea3 b\u1ec7nh nh\u00e2n \u0111\u1ec1u ph\u1ea3n \u1ee9ng gi\u1ed1ng nhau. M\u1ed9t s\u1ed1 ph\u00e1t tri\u1ec3n kh\u1ea3 n\u0103ng kh\u00e1ng thu\u1ed1c theo th\u1eddi gian, trong khi nh\u1eefng ng\u01b0\u1eddi kh\u00e1c kh\u00f4ng c\u00f3 ph\u1ea3n \u1ee9ng g\u00ec. \u0110\u1ec3 v\u01b0\u1ee3t qua nh\u1eefng tr\u1edf ng\u1ea1i n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang kh\u00e1m ph\u00e1 c\u00e1c t\u1ed5 h\u1ee3p thu\u1ed1c m\u1edbi v\u00e0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ti\u1ebfp c\u1eadn s\u00e1ng t\u1ea1o, nh\u01b0 li\u1ec7u ph\u00e1p t\u1ebf b\u00e0o ho\u1eb7c v\u1eafc-xin c\u00e1 nh\u00e2n h\u00f3a. Nh\u1eefng ti\u1ebfn b\u1ed9 n\u00e0y nh\u1eb1m t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3 c\u1ee7a li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch v\u00e0 gi\u1ea3m thi\u1ec3u t\u00e1c d\u1ee5ng ph\u1ee5, \u0111\u00f4i khi c\u00f3 th\u1ec3 nghi\u00eam tr\u1ecdng.<\/p>\n
Vi\u1ec7c s\u1eed d\u1ee5ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb n\u00e0y k\u1ebft h\u1ee3p v\u1edbi ph\u1eabu thu\u1eadt, x\u1ea1 tr\u1ecb ho\u1eb7c h\u00f3a tr\u1ecb c\u0169ng \u0111ang \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u. M\u1ee5c ti\u00eau l\u00e0 t\u1ed1i \u01b0u h\u00f3a k\u1ebft qu\u1ea3 v\u00e0 cung c\u1ea5p c\u00e1c gi\u1ea3i ph\u00e1p ph\u00f9 h\u1ee3p v\u1edbi t\u1eebng b\u1ec7nh nh\u00e2n, d\u1ef1a tr\u00ean \u0111\u1eb7c \u0111i\u1ec3m c\u1ee7a kh\u1ed1i u v\u00e0 t\u00ecnh tr\u1ea1ng s\u1ee9c kh\u1ecfe t\u1ed5ng th\u1ec3 c\u1ee7a h\u1ecd. Nh\u1edd nh\u1eefng ti\u1ebfn b\u1ed9 n\u00e0y, u \u00e1c t\u00ednh di c\u0103n, tr\u01b0\u1edbc \u0111\u00e2y \u0111\u01b0\u1ee3c coi nh\u01b0 m\u1ed9t \u00e1n t\u1eed h\u00ecnh, gi\u1edd \u0111\u00e2y tr\u1edf th\u00e0nh m\u1ed9t c\u0103n b\u1ec7nh c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t t\u1ed1t h\u01a1n, th\u1eadm ch\u00ed c\u00f3 th\u1ec3 ch\u1eefa kh\u1ecfi trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p.<\/p>\n
DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1007\/s11912-026-01750-1<\/a><\/p>\n Titre\u00a0:<\/strong> Immune Checkpoint Inhibitors in Malignant Melanoma: Anti-PD-1, Anti-CTLA-4 and Anti-LAG-3 Therapies<\/p>\n Revue : <\/strong> Current Oncology Reports<\/p>\n \u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n Auteurs : <\/strong> Andrea M. Allen-Tejerina; Periklis Giannakis; Thomas Ho Lai Yau; Christopher R. T. Hillyar; Kathrine S. Rallis<\/p>\n","protected":false},"excerpt":{"rendered":" Li\u1ec7u li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch c\u00f3 \u0111ang thay \u0111\u1ed5i c\u00e1ch \u0111i\u1ec1u tr\u1ecb u \u00e1c t\u00ednh di c\u0103n? U \u00e1c t\u00ednh, m\u1ed9t lo\u1ea1i ung th\u01b0 da \u00e1c t\u00ednh, v\u1eabn l\u00e0 m\u1ed9t trong nh\u1eefng b\u1ec7nh nguy hi\u1ec3m nh\u1ea5t do kh\u1ea3 n\u0103ng lan r\u1ed9ng nhanh ch\u00f3ng v\u00e0 kh\u1ea3 n\u0103ng kh\u00e1ng l\u1ea1i c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb truy\u1ec1n th\u1ed1ng… Continue reading Li\u1ec7u li\u1ec7u ph\u00e1p mi\u1ec5n d\u1ecbch c\u00f3 \u0111ang thay \u0111\u1ed5i c\u00e1ch \u0111i\u1ec1u tr\u1ecb u \u00e1c t\u00ednh di c\u0103n?<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-15","post","type-post","status-publish","format-standard","hentry","category-suc-khoe","entry"],"_links":{"self":[{"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/posts\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":1,"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/posts\/15\/revisions"}],"predecessor-version":[{"id":16,"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/posts\/15\/revisions\/16"}],"wp:attachment":[{"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/media?parent=15"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/categories?post=15"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/themedicaltribune.com\/vi\/wp-json\/wp\/v2\/tags?post=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}