{"id":33,"date":"2026-06-13T11:04:55","date_gmt":"2026-06-13T09:04:55","guid":{"rendered":"https:\/\/themedicaltribune.com\/zh-cn\/2026\/06\/13\/crispr%e5%b7%a5%e5%85%b7%e4%b8%ba%e5%91%bc%e5%90%b8%e9%81%93%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e6%8f%90%e4%be%9b%e6%96%b0%e6%ad%a6%e5%99%a8\/"},"modified":"2026-06-13T11:05:57","modified_gmt":"2026-06-13T09:05:57","slug":"crispr%e5%b7%a5%e5%85%b7%e4%b8%ba%e5%91%bc%e5%90%b8%e9%81%93%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e6%8f%90%e4%be%9b%e6%96%b0%e6%ad%a6%e5%99%a8","status":"publish","type":"post","link":"https:\/\/themedicaltribune.com\/zh-cn\/2026\/06\/13\/crispr%e5%b7%a5%e5%85%b7%e4%b8%ba%e5%91%bc%e5%90%b8%e9%81%93%e7%97%85%e6%af%92%e6%84%9f%e6%9f%93%e6%8f%90%e4%be%9b%e6%96%b0%e6%ad%a6%e5%99%a8\/","title":{"rendered":"CRISPR\u5de5\u5177\u4e3a\u547c\u5438\u9053\u75c5\u6bd2\u611f\u67d3\u63d0\u4f9b\u65b0\u6b66\u5668"},"content":{"rendered":"

CRISPR\u5de5\u5177\u4e3a\u547c\u5438\u9053\u75c5\u6bd2\u611f\u67d3\u63d0\u4f9b\u65b0\u6b66\u5668<\/h1>\n

\u547c\u5438\u9053\u75c5\u6bd2\u611f\u67d3\u662f\u5168\u7403\u5065\u5eb7\u9762\u4e34\u7684\u91cd\u5927\u6311\u6218\uff0c\u6bcf\u5e74\u6709\u6570\u5341\u4e07\u4eba\u56e0\u6d41\u611f\u75c5\u6bd2\u3001\u547c\u5438\u9053\u5408\u80de\u75c5\u6bd2\u6216SARS-CoV-2\u7b49\u75c5\u6bd2\u6b7b\u4ea1\u3002\u5c3d\u7ba1\u75ab\u82d7\u548c\u6297\u75c5\u6bd2\u836f\u7269\u53d1\u6325\u7740\u5173\u952e\u4f5c\u7528\uff0c\u4f46\u5176\u6709\u6548\u6027\u53ef\u80fd\u56e0\u75c5\u6bd2\u5feb\u901f\u8fdb\u5316\u548c\u8010\u836f\u6027\u51fa\u73b0\u800c\u53d7\u5230\u9650\u5236\u3002\u4e00\u79cd\u57fa\u4e8eCRISPR\u6280\u672f\u7684\u521b\u65b0\u65b9\u6cd5\uff0c\u80fd\u591f\u76f4\u63a5\u9488\u5bf9\u75c5\u6bd2\u7684\u9057\u4f20\u7269\u8d28\u6216\u5176\u590d\u5236\u6240\u9700\u7684\u7ec6\u80de\u56e0\u5b50\u3002<\/p>\n

\u8fd9\u79cd\u65b9\u6cd5\u4f7f\u7528\u53ef\u7f16\u7a0b\u9176\uff0c\u5982\u9488\u5bf9RNA\u75c5\u6bd2\u7684Cas13\u6216\u9488\u5bf9DNA\u75c5\u6bd2\u7684Cas9\u548cCas12\uff0c\u80fd\u591f\u5207\u5272\u7279\u5b9a\u7684\u75c5\u6bd2\u5e8f\u5217\u3002\u5728\u5b9e\u9a8c\u5ba4\u4e2d\uff0c\u5bf9\u4eba\u7c7b\u80ba\u7ec6\u80de\u57f9\u517b\u7269\u548c\u52a8\u7269\u6a21\u578b\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u5de5\u5177\u80fd\u591f\u964d\u4f4e\u6d41\u611f\u6216SARS-CoV-2\u7684\u75c5\u6bd2\u8f7d\u91cf\u3002\u4f8b\u5982\uff0c\u5c06Cas13a\u4ee5\u4fe1\u4f7fRNA\u7684\u5f62\u5f0f\u6ce8\u5c04\u5230\u5c0f\u9f20\u6216\u4ed3\u9f20\u7684\u80ba\u90e8\uff0c\u901a\u8fc7\u9f3b\u8154\u6216\u6c14\u6eb6\u80f6\u9014\u5f84\u7ed9\u836f\u540e\uff0c\u80fd\u591f\u663e\u8457\u51cf\u5c11\u75c5\u6bd2\u6570\u91cf\u3002<\/p>\n

\u8fd9\u9879\u6280\u672f\u7684\u4e00\u4e2a\u4e3b\u8981\u4f18\u52bf\u5728\u4e8e\u5176\u5feb\u901f\u9002\u5e94\u80fd\u529b\u3002\u901a\u8fc7\u9488\u5bf9\u75c5\u6bd2\u57fa\u56e0\u7ec4\u4e2d\u4fdd\u5b88\u533a\u57df\uff08\u5373\u4e0d\u6613\u53d1\u751f\u7a81\u53d8\u7684\u533a\u57df\uff09\uff0c\u7814\u7a76\u4eba\u5458\u964d\u4f4e\u4e86\u75c5\u6bd2\u9003\u9038\u7684\u98ce\u9669\u3002\u6b64\u5916\uff0c\u540c\u65f6\u4f7f\u7528\u591a\u4e2aRNA\u5bfc\u5411\u5e8f\u5217\u53ef\u4ee5\u9488\u5bf9\u57fa\u56e0\u7ec4\u7684\u591a\u4e2a\u90e8\u5206\uff0c\u4ece\u800c\u4f7f\u8010\u836f\u6027\u7684\u51fa\u73b0\u53d8\u5f97\u66f4\u52a0\u56f0\u96be\u3002\u8fd9\u79cd\u88ab\u79f0\u4e3a\u591a\u91cd\u5316\u7684\u7b56\u7565\u5df2\u5728\u5bf9\u6297SARS-CoV-2\u7684\u591a\u79cd\u53d8\u5f02\u682a\u4e2d\u8bc1\u660e\u4e86\u5176\u6709\u6548\u6027\uff0c\u5e76\u53ef\u80fd\u6269\u5c55\u5230\u5176\u4ed6\u547c\u5438\u9053\u75c5\u6bd2\u3002<\/p>\n

\u7136\u800c\uff0c\u5c06CRISPR\u5de5\u5177\u76f4\u63a5\u9012\u9001\u5230\u80ba\u90e8\u4ecd\u9762\u4e34\u6311\u6218\u3002\u75c5\u6bd2\u8f7d\u4f53\uff08\u5982\u817a\u75c5\u6bd2\uff09\u80fd\u5b9e\u73b0\u9176\u7684\u957f\u671f\u8868\u8fbe\uff0c\u4f46\u53ef\u80fd\u5f15\u53d1\u514d\u75ab\u53cd\u5e94\u6216\u5728\u8fd0\u8f93\u9057\u4f20\u7269\u8d28\u65f6\u5b58\u5728\u5c3a\u5bf8\u9650\u5236\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u8102\u8d28\u7eb3\u7c73\u9897\u7c92\u63d0\u4f9b\u4e86\u66f4\u7075\u6d3b\u7684\u89e3\u51b3\u65b9\u6848\u3002\u5b83\u4eec\u80fd\u591f\u5b9e\u73b0\u6682\u65f6\u6027\u8868\u8fbe\uff0c\u9002\u7528\u4e8e\u6025\u6027\u611f\u67d3\uff0c\u5e76\u4e14\u53ef\u4ee5\u901a\u8fc7\u6c14\u6eb6\u80f6\u65b9\u5f0f\u7ed9\u836f\u3002\u6700\u8fd1\u7684\u7814\u7a76\u5df2\u8bc1\u660e\u5176\u80fd\u591f\u6709\u6548\u5730\u5c06\u7f16\u7801Cas13\u7684\u4fe1\u4f7fRNA\u9012\u9001\u5230\u5c0f\u9f20\u80ba\u90e8\uff0c\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\u5e76\u663e\u8457\u964d\u4f4e\u75c5\u6bd2\u8f7d\u91cf\u3002<\/p>\n

CRISPR\u7684\u53e6\u4e00\u4e2a\u4f18\u52bf\u662f\u80fd\u591f\u8c03\u8282\u53c2\u4e0e\u75c5\u6bd2\u611f\u67d3\u7684\u7ec6\u80de\u56e0\u5b50\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u963b\u65ad\u732b\u86cb\u767d\u9176L\u7684\u8868\u8fbe\uff08SARS-CoV-2\u8fdb\u5165\u7ec6\u80de\u6240\u9700\u7684\u4e00\u79cd\u9176\uff09\uff0c\u53ef\u4ee5\u5728\u4e0d\u76f4\u63a5\u9488\u5bf9\u75c5\u6bd2\u7684\u60c5\u51b5\u4e0b\u51cf\u5c11\u611f\u67d3\u3002\u8fd9\u79cd\u65b9\u6cd5\u7684\u4f18\u70b9\u5728\u4e8e\u80fd\u591f\u964d\u4f4e\u8010\u836f\u6027\u98ce\u9669\uff0c\u56e0\u4e3a\u5b83\u9488\u5bf9\u7684\u662f\u4fdd\u5b88\u7684\u7ec6\u80de\u673a\u5236\uff0c\u800c\u975e\u4e0d\u65ad\u53d8\u5316\u7684\u75c5\u6bd2\u5e8f\u5217\u3002<\/p>\n

\u5269\u4f59\u7684\u6311\u6218\u5305\u62ec\u4f18\u5316\u9012\u9001\u65b9\u5f0f\uff0c\u4ee5\u907f\u514d\u7eb3\u7c73\u9897\u7c92\u88ab\u9ecf\u6db2\u6216\u80ba\u90e8\u9632\u5fa1\u673a\u5236\u6355\u83b7\uff0c\u4ee5\u53ca\u6700\u5c0f\u5316\u4e0d\u826f\u53cd\u5e94\uff0c\u5982\u9488\u5bf9CRISPR\u9176\u6216\u9012\u9001\u8f7d\u4f53\u7684\u514d\u75ab\u53cd\u5e94\u3002\u536b\u751f\u76d1\u7ba1\u673a\u6784\u8fd8\u8981\u6c42\u5728\u4e34\u5e8a\u5e94\u7528\u524d\u63d0\u4f9b\u5173\u4e8e\u7597\u6cd5\u5728\u4f53\u5185\u5206\u5e03\u3001\u6301\u4e45\u6027\u548c\u957f\u671f\u5b89\u5168\u6027\u7684\u53ef\u9760\u6570\u636e\u3002<\/p>\n

\u672a\u6765\uff0c\u5c06CRISPR\u6280\u672f\u4e0e\u5feb\u901f\u6d4b\u5e8f\u65b9\u6cd5\u76f8\u7ed3\u5408\uff0c\u53ef\u80fd\u5b9e\u73b0\u5b9e\u65f6\u4e2a\u6027\u5316\u7597\u6cd5\u3002\u901a\u8fc7\u5206\u6790\u60a3\u8005\u4f53\u5185\u75c5\u6bd2\u7684\u57fa\u56e0\u7ec4\uff0c\u53ef\u4ee5\u5b9a\u5236RNA\u5bfc\u5411\u5e8f\u5217\uff0c\u7cbe\u786e\u9488\u5bf9\u611f\u67d3\u7684\u75c5\u6bd2\u682a\u3002\u6b64\u5916\uff0c\u9884\u5148\u8bbe\u8ba1\u7684\u5bfc\u5411\u5e8f\u5217\u5e93\u53ef\u4ee5\u88ab\u50a8\u5b58\u5e76\u5feb\u901f\u90e8\u7f72\uff0c\u4ee5\u5e94\u5bf9\u75ab\u60c5\u7206\u53d1\uff0c\u4e3a\u65b0\u5174\u75c5\u6bd2\u63d0\u4f9b\u5373\u65f6\u5e94\u5bf9\u3002<\/p>\n

\u6700\u540e\uff0cCRISPR\u53ef\u4ee5\u4e0e\u5176\u4ed6\u65b9\u6cd5\uff08\u5982\u6297\u5fae\u751f\u7269\u80bd\u6216\u6297\u4f53\uff09\u7ed3\u5408\u4f7f\u7528\uff0c\u4ee5\u589e\u5f3a\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u79cd\u7ec4\u5408\u4e0d\u4ec5\u53ef\u4ee5\u6cbb\u7597\u75c5\u6bd2\u611f\u67d3\uff0c\u8fd8\u53ef\u4ee5\u51cf\u5c11\u6297\u751f\u7d20\u7684\u4f7f\u7528\uff0c\u4ece\u800c\u9650\u5236\u7ec6\u83cc\u8010\u836f\u6027\u7684\u51fa\u73b0\u3002\u968f\u7740\u9012\u9001\u3001\u5b89\u5168\u6027\u548c\u76d1\u7ba1\u65b9\u9762\u7684\u4e0d\u65ad\u8fdb\u6b65\uff0c\u57fa\u4e8eCRISPR\u7684\u7597\u6cd5\u53ef\u80fd\u4e0d\u4e45\u5c06\u6210\u4e3a\u5bf9\u6297\u547c\u5438\u9053\u611f\u67d3\u7684\u91cd\u8981\u6b66\u5668\u3002<\/p>\n

\n

Sources utilis\u00e9es<\/h2>\n

Source du rapport<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1007\/s44370-026-00045-0<\/a><\/p>\n

Titre\u00a0:<\/strong> CRISPR-based therapeutics to combat respiratory viral infections<\/p>\n

Revue : <\/strong> Discover Viruses<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Piyush Baindara; Roy Dinata<\/p>\n","protected":false},"excerpt":{"rendered":"

CRISPR\u5de5\u5177\u4e3a\u547c\u5438\u9053\u75c5\u6bd2\u611f\u67d3\u63d0\u4f9b\u65b0\u6b66\u5668 \u547c\u5438\u9053\u75c5\u6bd2\u611f\u67d3\u662f\u5168\u7403\u5065\u5eb7\u9762\u4e34\u7684\u91cd\u5927\u6311\u6218\uff0c\u6bcf\u5e74\u6709\u6570\u5341\u4e07\u4eba\u56e0\u6d41\u611f\u75c5\u6bd2\u3001… \u7ee7\u7eed\u9605\u8bfbCRISPR\u5de5\u5177\u4e3a\u547c\u5438\u9053\u75c5\u6bd2\u611f\u67d3\u63d0\u4f9b\u65b0\u6b66\u5668<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2,6],"tags":[],"class_list":["post-33","post","type-post","status-publish","format-standard","hentry","category-2","category-6","entry"],"_links":{"self":[{"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/posts\/33","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/comments?post=33"}],"version-history":[{"count":1,"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/posts\/33\/revisions"}],"predecessor-version":[{"id":34,"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/posts\/33\/revisions\/34"}],"wp:attachment":[{"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/media?parent=33"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/categories?post=33"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/themedicaltribune.com\/zh-cn\/wp-json\/wp\/v2\/tags?post=33"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}